Search results for "Controlled release systems"

showing 3 items of 3 documents

Enzyme-Mediated Controlled Release Systems by Anchoring Peptide Sequences on Mesoporous Silica Supports

2011

[EN] Gated community: Peptides anchored to the surface of silica mesoporous supports by a valid procedure act as gatekeepers. In this way, "zero release" supports that selectively deliver the cargo in the presence of a suitable peptidase are obtained (see picture, red spheres: cargo, colored chains: peptides). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

INGENIERIA DE LA CONSTRUCCIONPeptide sequencesStereochemistryPeptide hydrolaseMolecular Sequence DataAnchoringPeptideCatalysisRutheniumArticleAmino acid sequenceNanoparticleQUIMICA ORGANICACoordination ComplexesControlled release systemsSilicon dioxideControlled releaseOrganic chemistryMolecular geneticsValenciachemistry.chemical_classificationbiologyQUIMICA INORGANICAMesoporous supportSilicaGeneral ChemistryGeneral MedicineMesoporous silicaMolecular gatesbiology.organism_classificationControlled releaseMesoporous materialsChemistryKineticsEnzymeMetabolismchemistryMesoporous SilicaPeptide HydrolasesPeptideNanoparticlescontrolled releasePeptidesPorosityCoordination compoundmolecular gatesPeptide HydrolasesAngewandte Chemie
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Formulation of Mesoporous Silica Nanoparticles for Controlled Release of Antimicrobials for Stone Preventive Conservation

2020

The biotic deterioration of artifacts of archaeological and artistic interest mostly relies on the action of microorganisms capable of thriving under the most disparate environmental conditions. Thus, to attenuate biodeterioration phenomena, biocides can be used by the restorers to prevent or slow down the microbial growth. However, several factors such as biocide half-life, its wash-out because of environmental conditions, and its limited time of action make necessary its application repeatedly, leading to negative economic implications. Sound and successful treatments are represented by controlled release systems (CRSs) based on porous materials. Here, we report on the design and developm…

Biocidecondensation in emulsionNanoparticle02 engineering and technologyBacterial growth010402 general chemistrySettore BIO/19 - Microbiologia Generale01 natural sciencesKocuria rhizophilabiocideslcsh:Chemistrystone conservationSpecific surface areabiodeteriorationmesoporous silica nanoparticlesOriginal ResearchSettore CHIM/02 - Chimica Fisicacontrolled release systemsbiologyChemistryGeneral Chemistrycultural heritageMesoporous silica021001 nanoscience & nanotechnologybiology.organism_classificationControlled release0104 chemical sciencesChemistryChemical engineeringbiocides biodeterioration condensation in emulsion controlled release systems cultural heritage mesoporous silica nanoparticles stone conservationlcsh:QD1-999Emulsion0210 nano-technologyFrontiers in Chemistry
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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

2012

[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. In the first step, the pores of an inorganic MCM-41 support (in the form of nanoparticles) were loaded with [Ru(bipy) 3]Cl 2 complex, and then, in the second step, the pore outlets were functionalized with ester glycol moieties that acted as molecular caps. In the absence of an enzyme, release of the complex from aqueous suspensions of S1 at pH 8.0 is inhibited due to the steric hindrance imposed by the bulky ester glycol moieties. Upon addition of esterase enzyme, del…

Cell viabilityINGENIERIA DE LA CONSTRUCCIONEthyleneRuthenium complexesMCM-41 supportsCytotoxicityGlycol derivativesEsteraseFunctionalizedOrganic-inorganic hybrid solidsGlycolschemistry.chemical_compoundQUIMICA ORGANICATumor Cells CulturedElectrochemistryControlled release systemsOrganic chemistryControlled releaseGeneral Materials ScienceSteric hindrancesMCF-7 cellsSpectroscopyHydrolysisEsterasesSilicaEstersSurfaces and InterfacesSilicon DioxideCondensed Matter PhysicsControlled releaseChlorine compoundsEster bondsBody fluidsHybrid materialsHybrid materialPorosityCell deathCell SurvivalSurface PropertiesCytotoxic drugsRutheniumHydrolysisEnzymatic hydrolysisEsterase enzymesPolymer chemistryHumansCamptothecin (CPT)Molecular capSize reductionsTherapeutic ApplicationEthylene glycolTwo-step procedureEsterificationSuspensions (fluids)Ruthenium compoundsQUIMICA INORGANICAMesoporous supportOligo(ethylene glycol)Cell internalizationMolecular gatesConfocal microscopychemistryEnzymatic hydrolysisEnzyme-mediated hydrolysisNanoparticlesCamptothecinCell cultureMesoporous materialAqueous suspensionsEthylene glycolHeLa Cells
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